They are both male and female, with the latter being the first to perish.
According to Dr Zakaria, Director of the Medical Department of the Ghana Hajj Board (GHB), the lady died while doing one of the five daily prayers.
She collapsed during the prayers and died before being attended to by members of the medical team.
The male pilgrim died at the King Abdul Aziz Hospital in Mecca, where he had been admitted for two weeks due to a high sugar level in his body, according to the director.
Both travellers perished even before the Hajj ceremonies began, he noted.
He gave a positive overall review of Ghanaian pilgrims’ health management. He credited the success of health management to the surveillance system set up at the satellite medical units at the hotels where pilgrims stayed.
He was relieved to report that there had been no disease outbreaks such as COVID-19 or others.
Meanwhile, the first batch of Ghanaian pilgrims who were airlifted from Tamale Airport arrived Wednesday afternoon to the welcoming arms of their family members and well-wishers.
Three more flights are due to arrive, adding to the four that arrived in Madina, Saudi Arabia.
Pilgrims were given a bag as hand luggage at the time of departure from Ghana, and two more as major bags upon arriving in Saudi Arabia towards the start of the return journey.
Those who disobeyed the luggage carrier protocol had their bags denied on the first flights, and the same will be true on subsequent flights.
Those who exceed the weight restrictions must make their own arrangements for the extra luggage.